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KMID : 0043320150380112059
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Archives of Pharmacal Research
2015 Volume.38 No. 11 p.2059 ~ p.2065
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A new naphthalene glycoside from Chimaphila umbellata inhibits the RANKL-stimulated osteoclast differentiation
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Shin Byong-Kyu
Kim Jin-Hee
Kang Ji-Sung
Piao Hui Shan
Park Jeong-Hill
Hwang Gwi-Seo
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Abstract
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A new naphthalene glycoside was isolated from the leaves and stems of Chimaphila umbellata Barton. Its chemical structure was elucidated to be 2,7-dimethyl-1,4-dihydroxynaphthalene-1-O-β-d-glucopyranoside (DMDHNG), based on spectroscopic evidence. DMDHNG significantly inhibited the receptor activator of nuclear factor-κB ligand (RANKL)-induced tartrate-resistant acid phosphatase (TRAP) activity and the formation of multinucleated osteoclasts in a dose-dependent manner. In addition, the new glycoside inhibited the RANKL-induced mRNA expression of osteoclast-associated genes that encode TRAP, cathepsin K, and another transcription factor?nuclear factor of activated T-cells c1. We believe that the inhibitory effects of DMDHNG on the osteoclast differentiation may be exploited for a therapeutic benefit.
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KEYWORD
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Chimaphila umbellata, 2, 7-Dimethyl-1, 4-dihydroxynaphthalene-1-O-β-d-glucopyranoside, Osteoclast, Receptor activator of nuclear factor-κB ligand, Tartrate-resistant acid phosphatase
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